[Photo/VCG] BEIJING -- Chinese scientists have found a new therapeutic target for rejuvenating aging cells, shedding light on possible gene therapy for osteoarthritis. Osteoarthritis is characterized by the degeneration of articular cartilage, which seriously affects the quality of life of the elderly. Aging and mesenchymal stem cell attrition are considered the main causes of osteoarthritis. Therefore, revealing the molecular mechanisms of mesenchymal stem cell aging will provide clues for effective intervention for osteoarthritis. Scientists from the Institute of Biophysics of the Chinese Academy of Sciences (CAS), Peking University and the Institute of Zoology of the CAS have found that a protein named CBX4 safeguards mesenchymal stem cells against cellular aging, thus controlling the development of osteoarthritis. Experiments on mice show that the overexpression of CBX4 alleviates cellular senescence, inhibits inflammation and stimulates cartilage regeneration, thereby effectively controlling the pathological process of osteoarthritis. According to Liu Guanghui, one of the corresponding authors, the finding not only highlights CBX4 as a key gatekeeper for mesenchymal stem cell aging but also open possibilities for treating age-related disorders in the future. The research proves the feasibility of using gene therapy strategies to rejuvenate senescent cells and treat osteoarthritis, providing a promising option for future geriatrics and regenerative medicine, Liu said. The research was published in the journal Cell Reports. pink breast cancer silicone wristbandsrainbow rubber braceletspersonalized silicone wristbandsdesign your own rubber bracelet onlinesilicone wristbands
China's AG600, the world's largest amphibious aircraft, makes its maiden flight in December in Guangdong province. [Photo/Xinhua] XI'AN -- The China-developed AG600 large amphibious aircraft is expected to be delivered to customers by 2022, says manufacturer the Aviation Industry Corporation of China (AVIC). After its successful maiden flight in December last year, we are planning a ferry flight from its research base in Zhuhai to Jingmen, Central China's Hubei province, in July, said chief designer Huang Lingcai. Then, it will prepare for its first takeoff from water, scheduled for later this year, said Huang, also chief engineer of the AVIC General Aircraft Research Institute. Its first takeoff from water will take place at a large reservoir in Jingmen. Designed to be the world's largest amphibious aircraft, the AG600 will be mainly used for maritime rescue, fighting forest fires and marine monitoring, according to state-owned aviation giant AVIC. Codenamed Kunlong, the AG600 is undergoing test flights in Zhuhai, a coastal city in south China's Guangdong Province. With a range of up to 4,500 kilometers, it is designed to be capable of takeoff and landing in 2-meter waves. We are endeavoring to get the airworthiness certification from the civil aviation authorities by 2021, and deliver it to the customers by 2022, said Huang. customized silicone bracelets24 hour silicone wristbandscamo silicone wristbandsbusiness silicone wristbandsbuy wristbands<%2fcenter>
